They are coupled to light receptors similar to the ones in your eyes.

It's these receptors that are actually very important.

So in a daf 2 mutant you see that I have the X drawn here through the receptor.

Now let's zoom in on it here, so we can see it in more detail.

So what about the normal worm?

But you know there is much more to it,

But my favorite effect on the body is actually on the heart.

I just told you that, if you make a mutation in the daf 2 gene cell, that you get a receptor that doesn't work as well the animal lives longer.

I mean, I empathize with that person but I don't literally feel the touch.

How's he doing?

What that means is if you can tickle the fancy of this NMDA receptor, you'll put in more of these ordinary AMPA receptors into the synapse, and then the synapse will become stronger.

Why?

And why?

And the daf 2 gene encodes a hormone receptor.

And the other part is on the inside where it sends signals into the cell.

Take this example from rats.

Because our pheromones matched our olfactory receptors.

The altered immune receptors weren't effective.

So what you see in the picture there is a cell with a hormone receptor in red punching through the edge of the cell.

These hormones are similar to hormones that we have in our bodies.

And when it goes crazy, what it does is it activates all this machinery down here, and the effect of all that machinery is to put in more of these ordinary boring receptors.

Look at this kind, the NR receptor, also called the NMDA receptor.

Same thing with Receptin if you've got breast cancer.

When I first heard this theme,

Researchers Identify New Receptor Complex in Brain

This is how this works.

So in the fetal life, those testes are pumping out testosterone.

So our Pancreas is producing insulin and putting it into our bloodstream, so it's there to be used. but a situation can arise where the receptors are not working properly, and they have been desensitized to insulin.

And it seemed to me that there were three levels of acceptance that needed to take place.

When it is, it helps the rat cope with stressful situations.

I analyzed your blood isolating the receptor compounds and the proteinbased catalyst.

What is the latest report on Sgt. Jones?

She is very ill.

So, if you add enough insulin, there may be enough to bind with the insulin receptors and cause some glucose absorption.

It would be remiss of me to accept a statement made under duress.

His condition changed for the worse.

Tom's condition worsened.

The only problem here, and it's a big one, is that there is no insulin in the bloodstream. So, over here we can inject insulin.

And what they found was that people who lived to 90 or 100 were more likely to have daf 2 mutations that is, changes in the gene that encodes the receptor for IGF 1.

The condition of the patient turned for the better.

So after we made our discoveries with little C. elegans, people who worked on other kinds of animals started asking, if we made the same daf 2 mutation, the hormone receptor mutation, in other animals, will they live longer?

'Cause you might be thinking

You see this receptor? It's called an AMP receptor.

And we're understanding there're growth factors that go on, parts of these NR2B receptors are turned up, and the entire plasticity machinery is turned on along with these new baby cells.

Are there men around that table? Are there moms who've raised boys around that table?