There's a lot of mistakes to be made out there, and the immune system makes them.

Okay, we can start with that. I say no.

Bellini's lymphocemia. It's an autoimmune disease.

Let's flip the table yet again

But when it doesn't, we have to do something about that, therapeutically.

So, it's not an option for low income patients.

This is actually the cause of type I diabetes, juvenile diabetes or auto immune diabetes, it has several names.

I'll show you an example of that real quickly.

In the case of multiple sclerosis, the immune system attacks the insulating layers around the nerves in the brain and in the spinal chord.

About 80 of the body's immune cells reside in the gut, and immune abnormalities contribute to several neurological disorders.

Because 90 of suicides are related to a mental illness, depression, bipolar disorder, schizophrenia, anorexia, borderline personality, there's a long list of disorders that contribute, and as I mentioned before, often early in life.

But, as a cancer doc, this is what I see.

Ones gotta insist that this is a physical disease, that this is not a psychiatric disease.

This is one of those signals that the immune system sees in patients who have a disease called type 1 diabetes.

Even just in the last few years, patients with diseases like rheumatoid arthritis and multiple sclerosis and inflammatory bowel disease have a whole new set of therapeutic options that are directed at this re education process.

They didn't have M.E. but they had other chronic illnesses, auto immune diseases and

I have Friedreich's ataxia, a neuromuscular disease.

And even in the case when a disease occurs in both men and women, that disorder can be much more severe or have more severe consequences in one sex than the other.

This is one mechanism by which the bacterium Bacteroides fragilis prevents a mouse version of multiple sclerosis.

She suffers from a chronic illness.

And there were a few.

So dystonia is a disorder affecting children.

He was taken off the Dutch ship in Martinique and died a week later of consumption. Oh...

And excessive use of antibiotics, in particular in children, has been shown to be associated with, again, risk factors for obesity, for autoimmune diseases, for a variety of problems that are probably due to disruption of the microbial community.

And what the DNA sequencing technologies are allowing people to do now is do detailed studies of, say, 100 patients who have Crohn's disease and 100 people who don't have Crohn's disease.

These are years that we could get.

This was at a time that treatment actually existed in rich countries.

OK. Now let's move from sleep to diseases.

He'd probably had an injury as a child.

Pemphigus, vitiligo, those are examples of the immune system attacking the skin.

So a real skyrocketing of chronic childhood disease that includes other things

If you include immune mediated diseases like asthma and allergy, where the immune system is also over active and making mistakes, between 15 and 20 percent of us have these diseases.

Here's an example from Kevin Eggan's lab at Harvard.

Similarly, we have the tools with which to ask the question

In addition, it is rarely ordered because pancreatic cancer is, what we call, non symptomatic disease.

Another way by which microbes can affect the brain is by activation of the immune system.

The idea that a given node is central if it has short path to other nodes in the network.

It was a study to specifically ask, what's going on with women?

And this is, in 2004, the FDA has approved MR guided focused ultrasounds for the treatment of symptomatic uterine fibroids.

Dean, how bad is it?

They drank way too much, and they can't make new memories.

Chronic Fatigue Sundrome.

Lupus a long term, autoimmune disorder with devastating consequences that can result in death, for every man who is suffering from Lupus, there are 6 women who is suffering from this disorder.

I have allergic rhinitis.

I have chronic rhinitis.