Now, that inability to properly pump not just the cell, but the whole heart that is heart failure.

And let me actually show you where the blood vessels come from. These are called coronary vessels I just write the word coronary here.

40 percent of our coronary artery disease patients in our communities receive incomplete or inappropriate care.

He's dying. Coronary blockage.

They're taking the de oxygenated blood away from the tissue of the heart.

If the average age in your country is 45 to 55, now the average person is looking at diabetes, early onset diabetes, heart failure, coronary artery disease things that are inherently more difficult to treat, and much more expensive to treat.

Officially, they're characterizing that it was a coronary brought on by systemic shock.

Coronary vessels So, coronary artery and vein.

Or from the point of view of the person whose heart it is, it's on the left.

This right over here is called the left coronary artery or LCA.

So ischemia is deprivation of blood flow and oxygen downstream from this right over there.

There's a second big project, recently funded by the Wellcome Trust in this country, involving very large studies thousands of individuals, with each of eight different diseases, common diseases like type 1 and type 2 diabetes, and coronary heart disease, bipolar disease and so on to try and understand the genetics.

18.Rare diseases

And you can see, it's lumpy bumpy.

We started by organizing image acquisition from magnetic resonance and CT imaging machines, from which to make a model of the patient's aorta.

And so when people talk about arteries getting blocked or getting clogged, they're talking about the coronary arteries.

No heart disease, nocturnal asthma or sleep apnea.

That's what we call coronary artery disease, or heart disease.

300 to 500 million cases are reported.

I want to tell you about another disorder.

Now when we talk about suicide, there is also a medical contribution here.

She graduated NYU, she has a heart condition.

So what happens when a person gets a retinal degenerative disease like macular degeneration?

That's not very nice, but, after all, we had to find out what the answer is.

Three years later, he's ripping through boot camp. Attending physician calls the improvement in his bloodcell count miraculous.

I have Friedreich's ataxia, a neuromuscular disease.

So we developed the AngelMed Guardian System and we have a device inside this patient, called the Implanted AngelMed Guardian.

Well, what is needed for the earliest possible warning of a heart attack?

Why does this matter?

These are years that we could get.

Some of you may remember that.

Elyn, you don't really understand

Okay, we can start with that. I say no.

Bellini's lymphocemia. It's an autoimmune disease.

It's made a mistake.

His vitals are spiking.

This is a place where the oldest living female population is found.

But, as a cancer doc, this is what I see.

And then, when the heart is ready to pump it back out, it goes into this artery, and the name of it is the aorta.

The syndrome, the female pattern now is called microvascular coronary dysfunction, or obstruction.

Because we understand very little about most human diseases.

like Parkinson's or essential tremor.

It's similar to the pellagra epidemic in Mississippi in the '30s.

I'll show you an example of that real quickly.

When I travel around, I ask my colleagues in biomedical research