He died from acute lymphoblastic leukemia.

And bone marrow is actually what we use to save the lives of tens of thousands of patients, most of whom have advanced malignancies like leukemia and lymphoma and some other diseases.

Henriapi illustrates this phenomenon as well.

Only instead of, you know, good and bad cancer tumors or benign or malignant tumors we instead have diabetes or not and so we will use that as a supervised, we will solve that as a Supervised Learning problem just like we did for the breast tumor data.

Muscle aches and pains, gums get sore and bleed.

Endolymph fluid.

I won't go into this very much, but our technology, besides being able to tag tumor and metastatic lymph nodes with fluorescence, we can also use the same smart three part molecule to tag gadolinium onto the system so you can do this noninvasively.

But often there is this intuition that the negative class is conveying the absence of something, like the absence of a malignant tumor, whereas one, the positive class, is conveying the presence of something that we may be looking for.

So on. So this example...

Gone to your lymph nodes.

So 0 may denote the benign tumor and 1 positive class may denote a malignant tumor.

And people are suffering from all kinds of pain

No pain.

So, if angiogenesis is a tipping point between a harmless cancer and a harmful one, then one major part of the angiogenesis revolution is a new approach to treating cancer by cutting off the blood supply.

If someone discovers a breast tumor, a lump in their breast, a malignant tumor is a tumor that is harmful and dangerous and a benign tumor is a tumor that is harmless.

We didn't sequence his genome.

Here's an example of a training set for a classification task for classifying a tumor as malignant or benign and notice that malignancy takes on only two values zero or no or one or one or yes.

That's counterindicative for a hemorrhagic tumor.

And, really, this is the fourth of these molecules to kind of graduate from our little pipeline of drug discovery, two of which a topical drug for lymphoma of the skin and an oral substance for the treatment of multiple myeloma will actually come to the bedside for the first clinical trial in July of this year for us, a major and exciting milestone.

Provide direct compression over the carpal tunnel on the lower side of the wrist for up to thirty seconds.

Perform a Tinel's by tapping over the carpal tunnel.

Fully flex wrists and adduct dorsal surfaces of hands together.

That's another classification problem, and earlier we also talked about the example of classifying tumors as a cancerous malignant or as benign tumors.

Mice with multiple myeloma, an incurable malignancy of the bone marrow, respond dramatically to the treatment with this drug.

No pain, no gain.

Use plenty of it, all around the house.

Internal organs, lymphatic system, the works.

Walt, your tumor has shrunk by 80 percent.

And then if that node has cancer, the woman would go on to get the axillary lymph node dissection.

My headache has gone.

My headache is gone.

My head doesn't ache anymore.

I feel so helpless.

I got no pain.

If that some place else where it bulges is inside the biggest nerve in your body, your brain, you get a vascular migraine.

Tumors?

And you say, Oh my God,

And the good news has to do with what we know based on biomedical research that actually has changed the outcomes for many very serious diseases.

Let's start with leukemia, acute lymphoblastic leukemia, ALL, the most common cancer of children.

It's a very, very deadly type of cancer called an angiosarcoma.

Stage 3a, which means it's spread from the lung to the lymph nodes.

Victim's throat was swollen, probably from the effort... and there was a point when he passed out.

It's painful making love.

The cancer.

Took out most o9 the lymph nodes.