And the other really interesting thing is that when skeletal muscle there's been several reports that when skeletal muscle is injured, that's what correlates with metastases going to skeletal muscle.

So I decided to ask why.

Skeletons...

It needs to be constantly contracting, so therefore it's almost selfish. It's grabbing its blood vessels for itself.

So, there's so much interplay here.

MyoD acts upon these tumor cells and causes them to become skeletal muscle cells?

Endoskeletons.

The fetus' continual movement in the womb is necessary for muscular and skeletal growth.

So angiogenesis is really a central process to the pathogenesis of cancer.

And skeletal muscle constitutes 50 percent of our body, or over 50 percent of our body.

But once it starts moving throughout the body, that's when it becomes deadly.

The lumbar spine, the sacroiliac joint, the sacrum, the gluteus maximus muscle, the piriformis muscle, the sciatic notch, the ischial tuberosity, and the adductor tubercle of the proximal femur.

Some of my hypotheses are that when you first think about skeletal muscle, there's a lot of blood vessels going to skeletal muscle.

So, is it possible that the tumor cells are going to the skeletal muscle tissue, but once in contact inside the skeletal muscle tissue,

Those are its targets.

I should clarify that.

Two elements that worked for me here are the first is 90 percent, I learned, of head and neck pain is through muscular skeletal imbalance.

(English captions by Andrea Matsumoto from the University of Michigan)

It's strange, but it's like deeper it's muscle, vein, nerve, bone.

They use a skeleton that we call a hydrostatic skeleton.

There's an outer layer and an inner layer.

You can also see... my skeleton, (Laughter)

50 kilos for the entire fuselage.

It's a little distorted, but I don't think it's the computer.

Also in the seated position, palpate anatomic landmarks for tenderness.

Well, not the one we tagged!

(English captions by Andrea Matsumoto from the University of Michigan)

All of those muscles work in a pattern along the back side of the body, the back half of the body.

But it struck me that I'd never heard of cancer of the heart, or cancer of any skeletal muscle for that matter.

We found this last year.

Still working my way around endoskeleton.

You're supposed to burn the endos.

Damn it, Cameron, you're supposed to burn the endos.

So let me show you,

What I'm going to do is

I notice they react completely differently.

We needed the subtleties of the skin.

It cut right through skin, muscle and cartilage in one fell swoop.

English captions by Jade Cheng from the University of Michigan

(English captions by Jade Cheng from the University of Michigan)

These are being layered, one layer at a time, first the bone, we fill in the gaps with cartilage.

Maybe tumor cells are being disguised as skeletal muscle cells, and this is why it seems as if it is so rare.

If I push a little bit harder, I'll go through the skin, and I can feel the bone structure inside.

Its exoskeleton is beginning to fracture.

Two 600 models had a titanium alloy endoskeleton.