(Applause)

So it's, to me, an extraordinarily exciting time.

Attention deficit disorder, bipolar disorder.

Dolores was insane. Manicdepressive. Suicidal.

The same with the whole things on mania and stress and depression, unless it is so clinically brutal, man.

She's clearly manicdepressive.

When Steve Jurvetson and Jim Clark and Jim Barksdale have all got it, and they built Netscape imagine if they were given Ritalin.

Anyone can take Pleo and they can totally redo his personality.

And in that process that's going to morph from being just for diseases, to being for lesser vulnerabilities,

Ah well.

Giggles You really are having a midlife crisis, huh?

That is because we are talking about disability.

It's probably why I'm a little bit panicked right now other than all the caffeine that I've had and the sugar but this is really creepy for an entrepreneur.

The World Health Organization now estimates that one out of five people on the planet is clinically depressed.

There's a movement going on right now to reframe mental illness as a positive at least the hypomanic edge part of it.

You're probably just having a midlife crisis.

I hope your Porsche works out.

And sometimes, health differences can arise in these children.

If you are happy about something, you'll go more to the left side.

Clinical depression has exploded in the industrial world in the last generation.

Creativity, innovation, and transformation... are all merely side effects, of our desires and abilities to empathize, and to connect.

The last thing that's remarkable about the Tarahumara is all the things we're going to be talking about today, all the things we're trying to use all of our technology and brain power to solve things like heart disease and cholesterol and cancer crime, warfare and violence clinical depression all this stuff the Tarahumara don't know what you're talking about.

Yumi...you have such a vibrant personality..

It's annoying.

Now, the program says that the opposite of play is not work, it's depression.

CDC Antidepressant use skyrockets 400 in past 20 years

She felt blue.

I was tired of working and wasted time everyday.

I have the blues today.

It's a decongestant.

No, I'm not going to any depressing shit like that. Too sensitive.

In fact, without the optimism bias, we would all be slightly depressed.

And we all become a little bit hypomanic.

Hence, loathed melancholy.

Brian looks blue.

He was in a mood of depression.

I always feel blue on Mondays.

Tom fell into depression from working too hard.

Our great war is the spiritual war.

I'm depressed.

I can't remember that.

This job gives me the hump.

I was feeling blue all day.

And we're so excited.

There's that nasty bug that's going around.