Doug The files.

loss of cortical gray matter.

One is called RELN it's involved in early developmental cues.

This person is likely to have some form of schizophrenia.

Let's start with the definition of schizophrenia.

If you hear nothing else today, please hear this

I can connect them to my reality, and I can make my dreams come true?

Okay, Josh, why don't we give you some why don't we give you some Zyprexa.

The other one also, but maybe too many patterns.

You humans like to talk, right? GLaDOS

And in the lab, we were asking the question,

Eight years since the FBI

That is because we are talking about disability.

As we think about this, probably it's better to actually go a little deeper into one particular disorder, and that would be schizophrenia, because I think that's a good case for helping to understand why thinking of this as a brain disorder matters.

That we could understand the causality of the mental illnesses.

Now, we don't have really any evidence of it, but I think, to give you a hypothesis, the best guess is that if you're left handed, you're prone to schizophrenia.

Immediately after the appointment with Kaplan,

There are not schizophrenics.

I grew up to study the brain because I have a brother who has been diagnosed with a brain disorder, schizophrenia.

I hasten to add that it's my experience, because everyone becomes psychotic in his or her own way.

Because 90 of suicides are related to a mental illness, depression, bipolar disorder, schizophrenia, anorexia, borderline personality, there's a long list of disorders that contribute, and as I mentioned before, often early in life.

As a young woman, I was in a psychiatric hospital on three different occasions for lengthy periods.

I think that's a good case for helping to understand why thinking of this as a brain disorder matters.

You can give the competing drug in too high a dose, so that people get side effects.

I have Friedreich's ataxia, a neuromuscular disease.

Or, you know, were they normal? I would guess they're normal.

DlSC1 is a gene that's deleted in schizophrenia.

I witnessed how music was able to bring him back from his very darkest moments, from what seemed to me in my untrained eye to be the beginnings of a schizophrenic episode.

Eleanor, you'd be better off with cancer, because cancer is easier to cure than schizophrenia.

And to date, there has been a sort of a schizophrenia in the donor community, as to how to build basic services in post conflict sectors.

You can do this in groups as well.

But you can see actually they are further down this list, and that's because we're talking here about disability.

Lets develop line ministries of this, that, and the other, that deliver these services.

So for example, lets sort of consider that basket cell I told you about earlier the one that's atrophied in schizophrenia and the one that is inhibitory.

I'm just saying that, if you think, oh, I don't carry a left handed gene so therefore my, you know, children won't be at risk of schizophrenia.

Contrary to what many people think, schizophrenia is not the same as multiple personality disorder or split personality.

It's funny, my wife, Daisy, whose family is littered with schizophrenics and I mean littered with them once said to me, Chris, I already have a brother who thinks he's God.

As we think about this, maybe it's better to actually go a little deeper into one particular disorder.

These are scans from Judie Rapoport and her colleagues at the National Institute of Mental Health, in which they studied children with very early onset schizophrenia.

But such ardent watchfulness can lead to anxiety, so much so that years later, when I was investigating why so many young black men were diagnosed with schizophrenia, six times more than they ought to be,

And so, I'll conclude by saying we've looked at 20 people with schizophrenia.

Let's consider here the case of Dilated Cardiomyopathy.

The first really big health issue is a word that Murray Schafer coined schizophonia.

There's a class of cells, a fairly small cell, an inhibitory cell, that quiets its neighbors.

I NEED them. I've been saving them for the right time. I'm sorry.