So in the fetal life, those testes are pumping out testosterone.

These hormones are similar to hormones that we have in our bodies.

But my favorite effect on the body is actually on the heart.

And the daf 2 gene encodes a hormone receptor.

I just told you that, if you make a mutation in the daf 2 gene cell, that you get a receptor that doesn't work as well the animal lives longer.

So what you see in the picture there is a cell with a hormone receptor in red punching through the edge of the cell.

They are coupled to light receptors similar to the ones in your eyes.

Paul, that is the world's stupidist idea.

So after we made our discoveries with little C. elegans, people who worked on other kinds of animals started asking, if we made the same daf 2 mutation, the hormone receptor mutation, in other animals, will they live longer?

It's these receptors that are actually very important.

It's a stress hormone.

So in a daf 2 mutant you see that I have the X drawn here through the receptor.

The daf 2 hormone receptor is very similar to the receptor for the hormone insulin and IGF 1.

Now let's zoom in on it here, so we can see it in more detail.

So what about the normal worm?

The answer that I receive, most frequently is,

So given a dataset

Electronegativity

One of 'em makes people glow in the dark.

Estrogen level's been low these days.

But you know there is much more to it,

They're in the back of our body.

So our Pancreas is producing insulin and putting it into our bloodstream, so it's there to be used. but a situation can arise where the receptors are not working properly, and they have been desensitized to insulin.

I mean, I empathize with that person but I don't literally feel the touch.

So, if you add enough insulin, there may be enough to bind with the insulin receptors and cause some glucose absorption.

How's he doing?

And we're understanding there're growth factors that go on, parts of these NR2B receptors are turned up, and the entire plasticity machinery is turned on along with these new baby cells.

What that means is if you can tickle the fancy of this NMDA receptor, you'll put in more of these ordinary AMPA receptors into the synapse, and then the synapse will become stronger.

Why?

And why?

And the other part is on the inside where it sends signals into the cell.

There's lust, which is just wanting to have sex.

female eggs were to be fertilized in a lab and given a cocktail of growth hormones.

Take this example from rats.

Because our pheromones matched our olfactory receptors.

The altered immune receptors weren't effective.

The tuberculin reaction was negative.

Give me two units, Onegative.

Physiologically, there also are differences on two key hormones testosterone, which is the dominance hormone, and cortisol, which is the stress hormone.

Those little blue dots on the top are the transmitters released by the axon, and then they activate all of these receptors, and all of that machinery in the next neuron, and ultimately that causes the neuron to fire.

And when it goes crazy, what it does is it activates all this machinery down here, and the effect of all that machinery is to put in more of these ordinary boring receptors.

Look at this kind, the NR receptor, also called the NMDA receptor.

Same thing with Receptin if you've got breast cancer.

But because this individual lacks receptors to hear that testosterone, the body doesn't react to the testosterone.

When I first heard this theme,