I'll write it out again because I want to make sure we see clearly the difference between someone with compliant blood vessels and someone with non compliant vessels.

Blood flows through blood vessels.

It's gonna be going initially through a giant vessel.

And the capsules in her blood stream.

And once those vessels invade the cancer, it can expand, it can invade local tissues, and the same vessels that are feeding tumors allow cancer cells to exit into the circulation as metastases.

Blood runs in the veins.

And what we do is we, to make a blood vessel, same strategy.

You know, where did these things come from?

Again, fairly more complex organs, but by far, the most complex solid organs are actually the vascularized, highly vascularized, a lot of blood vessel supply, organs such as the heart, the liver, the kidneys.

We can do this because tumor blood vessels are unlike normal, healthy vessels we see in other places of the body they're abnormal, they're very poorly constructed, and because of that, they're highly vulnerable to treatments that target them.

Shut your mouth!

We can abstract them and to create something that is new.

more importantly the shape of a woman's womb.

like red blood cells.

(Laughter)

Subdural hematoma.

And this outer layer, this is the vasculature, which is incredible, around a human brain.

Thrombosis is the process of a thrombus forming.

End to end, that would form a line that would circle the earth twice.

Insurance will cover the bypass, it'll cover the angioplasty it won't, until recently, cover diet and lifestyle.

And this turns out to be one of our most important defense mechanisms against cancer.

But you have these two centrosomes, and they facilitate the development of these microtubules, which are

So, all these guys over here, these are the true capillaries.

So let's zoom in on one of them....Maybe we can zoom in right over here, that part of the artery.

All the sudden you could have these clotting factors form a clot right over here right at the actual plaque.

But there was something left.

Then you start to take a look at adult life.

Can't seem to find a vein.

Oh,clip that bleeder,Mr. Palmer.

Retract the duct a little more laterally.

Now, the remarkable thing about blood vessels is that they have this ability to adapt to whatever environment they're growing in.

And this is an X ray showing you the patent, functional blood vessel.

The walls are covered with villi where nutrient absorption takes place.

The heart is taking a quick breather to refill.

And the bottom curve is the weight of a normal mouse.

There are other situations where we start beneath the baseline, and we need to grow more blood vessels, just to get back to normal levels for example, after an injury and the body can do that too, but only to that normal level, that set point.

Because some of that pressure energy got taken away and stored as elastic energy.

And the Arotic valve is going to be what divides the left ventricle from this giant vessel that we talked about earlier.

And so specifically you might hear about a coronary artery, or a coronary vein, but together you can call them coronary blood vessels.

You can also sew bypass vessels directly onto a beating heart without cracking the chest.

Evidence of an extradural hematoma.

Blood sample came back. Not a match to the plastic surgeon's office.

Some of you may remember that.

So we thought the patient might actually want to know the context as well.

Yes.