Doug The files.

loss of cortical gray matter.

One is called RELN it's involved in early developmental cues.

This person is likely to have some form of schizophrenia.

Let's start with the definition of schizophrenia.

I can connect them to my reality, and I can make my dreams come true?

That is because we are talking about disability.

If you hear nothing else today, please hear this

As we think about this, probably it's better to actually go a little deeper into one particular disorder, and that would be schizophrenia, because I think that's a good case for helping to understand why thinking of this as a brain disorder matters.

Now, we don't have really any evidence of it, but I think, to give you a hypothesis, the best guess is that if you're left handed, you're prone to schizophrenia.

The other one also, but maybe too many patterns.

You humans like to talk, right? GLaDOS

And in the lab, we were asking the question,

Eight years since the FBI

Because 90 of suicides are related to a mental illness, depression, bipolar disorder, schizophrenia, anorexia, borderline personality, there's a long list of disorders that contribute, and as I mentioned before, often early in life.

Immediately after the appointment with Kaplan,

That we could understand the causality of the mental illnesses.

There are not schizophrenics.

I grew up to study the brain because I have a brother who has been diagnosed with a brain disorder, schizophrenia.

I hasten to add that it's my experience, because everyone becomes psychotic in his or her own way.

Okay, Josh, why don't we give you some why don't we give you some Zyprexa.

But you can see actually they are further down this list, and that's because we're talking here about disability.

I think that's a good case for helping to understand why thinking of this as a brain disorder matters.

I'm just saying that, if you think, oh, I don't carry a left handed gene so therefore my, you know, children won't be at risk of schizophrenia.

DlSC1 is a gene that's deleted in schizophrenia.

As a young woman, I was in a psychiatric hospital on three different occasions for lengthy periods.

Or, you know, were they normal? I would guess they're normal.

But such ardent watchfulness can lead to anxiety, so much so that years later, when I was investigating why so many young black men were diagnosed with schizophrenia, six times more than they ought to be,

You can give the competing drug in too high a dose, so that people get side effects.

I witnessed how music was able to bring him back from his very darkest moments, from what seemed to me in my untrained eye to be the beginnings of a schizophrenic episode.

I have Friedreich's ataxia, a neuromuscular disease.

And to date, there has been a sort of a schizophrenia in the donor community, as to how to build basic services in post conflict sectors.

Eleanor, you'd be better off with cancer, because cancer is easier to cure than schizophrenia.

Lets develop line ministries of this, that, and the other, that deliver these services.

So for example, lets sort of consider that basket cell I told you about earlier the one that's atrophied in schizophrenia and the one that is inhibitory.

These are scans from Judie Rapoport and her colleagues at the National Institute of Mental Health, in which they studied children with very early onset schizophrenia.

You can do this in groups as well.

Contrary to what many people think, schizophrenia is not the same as multiple personality disorder or split personality.

It's funny, my wife, Daisy, whose family is littered with schizophrenics and I mean littered with them once said to me, Chris, I already have a brother who thinks he's God.

What are the biological differences between the brains of individuals who would be diagnosed as normal control, as compared with the brains of individuals diagnosed with schizophrenia, schizoaffective or bipolar disorder?

The first really big health issue is a word that Murray Schafer coined schizophonia.

As we think about this, maybe it's better to actually go a little deeper into one particular disorder.

I NEED them. I've been saving them for the right time. I'm sorry.

And in older age conditions like Parkinsonism, and in other acquired impairments like schizophrenia.

And so, I'll conclude by saying we've looked at 20 people with schizophrenia.