An obese man.

He is overweight.

A fat boy, too !

People are dying from curable diseases in South Central, Los Angeles.

What'd I just watch? (men singing dramatic tune in Japanese) (kid screams) Aah!

I think he's 1 100 pounds of baby fat.

On the far left, you see the purple line.

Vicki. Victoria was an overweight Queen.

People are dying from curable diseases in South Central Los Angeles.

I suffer from obesity.

And the patients started drifting in.

This is what happened to the children of the Dutch Hunger Winter.

Why would someone leave their home to go for a brisk walk in a toxic neighborhood?

And the bottom curve is the weight of a normal mouse.

But obviously the bigger problem that we all know about is obesity, and it's dramatic.

Americans have been told to eat less fat, the percent of calories from fat is down,

So my first topic with respect to this, was not death, but obesity.

Futureless language speakers are 20 to 24 percent less likely to be smoking at any given point in time compared to identical families, and they're going to be 13 to 17 percent less likely to be obese by the time they retire, and they're going to report being 21 percent more likely to have used a condom in their last sexual encounter.

I was fat as a boy.

Maybe we should be asking ourselves, is it possible that insulin resistance causes weight gain and the diseases associated with obesity, at least in most people?

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

He's a fat boy.

But what if we have it backwards?

The numbers are pretty crazy.

That happens in less than 2 of our missions.

Can we shrink fat by cutting off its blood supply?

I'm on my third generation of kids that they're getting bigger.

And those have been linked then with the rather alarming, growing rates of obesity, shown in these maps here, and that obesity has also been triggering great increases in heart disease and diabetes to the point where a child born today has a one in three chance of developing diabetes.

I did this and lost 40 pounds, weirdly while exercising less.

And just to show you this, this is from the CDC.

Are you packing it on?

Found them in the fat boy's stomach... mixed in with the food.

This here shows, on the Y axis, the increase in the probability that a person is obese given that a social contact of theirs is obese and, on the X axis, the degrees of separation between the two people.

And underlying these questions,

Cause and effect.

Let's look at some suggestive facts.

In addition, because obesity is not a unicentric epidemic, there's not a Patient Zero of the obesity epidemic if we find that guy, there was a spread of obesity out from him it's a multicentric epidemic.

He was well built, if not fat as such.

PCBs, DDT cross the placenta and effectively determine the likelihood of developing breast cancer and obesity and diabetes already when the baby's in the womb.

And if you're above 25, let's say 25 to 30, then you're in the overweight range.

Why not bring a fat boy, too?

So this approach that we're taking for cancer prevention may also have an application for obesity.

So if you put these physiological processes to work,

Big, but five years old.

I did the 23andMe thing and was very surprised to discover that I am fat and bald.