I mean, I'm a dermatologist.

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.

Ultraviolet rays can cause skin cancer.

And the star on his skin?

They throw up anti access, area denial asymmetrical strategies.

Cancer.

Cancer.

From cancer?

Well, you know, that's the point.

They are such an embarrassment!

I have cancer.

By the time you've reached 80, this is unlikely to happen to you.

Might as well not allow them to take the test!

Like you have cancer,

We are dying to see you all. Miss you guys a lot.

We needed the subtleties of the skin.

But I think this is actually just the beginning of how we're going to treat cancer.

Now in medical science, we don't want to know, necessarily, just how cancer works, we want to know how your cancer is different from my cancer.

So let me move to cancer.

It's brain cancer.

Rose... has cancer.

Cancer, wasn't it?

We are all aware of the risk of cancer, but there's another disease that's destined to affect even more of us arthritis.

It's important if you try to model this.

The destination death row, state prison.

The irony.

Oaky. Okay.

He died of cancer.

My wife died of cancer.

Tom died of cancer.

You have cancer.

There are words that we're truly afraid of.

It's a system of systems.

Well, so what I read on WebMD

In those days, I was living in a fool's paradise.

(Laughter)

I'm having a problem with cancer.

My little baby sister has cancer.

But 18 years ago Natoma was diagnosed with cancer.

It's of relevance to us.

You think that's ironic?

Double irony.

Skin.

And then we do a clinical trial for a drug for lung cancer and one for prostate cancer and one for breast cancer, and we treat these as if they're separate diseases and that this way of dividing them had something to do with what actually went wrong.

And that is where the research began.