And that is where the research began.

In fact, one in 70 women will be diagnosed with ovarian cancer.

One in 100 will die from it.

In fact, it's one of the biggest problems with chemotherapy today.

And so, please consider this a work in progress, but I'd like to tell you today a story about a very rare cancer called midline carcinoma, about the undruggable protein target that causes this cancer, called BRD4, and about a molecule developed at my lab at Dana Farber Cancer Institute, called JQ1, which we affectionately named for Jun Qi, the chemist that made this molecule.

I think we have found the problem. Your ovarian follicles are still immature.

Some people who have XX chromosomes develop what are called ovotestis, which is when you have ovarian tissue with testicular tissue wrapped around it.

Or being in a position like Lance Armstrong,

She lays her eggs in other nests

Your ovaries look fine.

In the immortal germ line of human beings that is, the eggs that sit in the ovaries they actually sit there in a state of suspended animation for up to 50 years in the life of each woman.

Then one day, there's a big egg in it.

I mean, I'm a dermatologist.

Cisplatin is a relatively common ovarian cancer chemotherapy drug a relatively simple molecule made in the lab that messes with the DNA of cancer cells and causes them to kill themselves.

These are the dissected gonads of an animal that has two testes, two ovaries, another large testis, more ovaries, which is not normal ... (Laughter) even for amphibians.

The hen was sitting on the eggs in the nest.

My response, A ton of hardwork and a lot of failures.

They push the other eggs out of the nest

The first cancer was done, which was brain cancer.

A single four foot female had 300 million eggs, can carry 300 million eggs in her ovaries imagine and they get to be over 10 feet long.

In some cases, another species like the North American Leopard Frog showed that males exposed to atrazine grew eggs in their testes.

The protein I found was called mesothelin.

One Flew Over the Cuckoo's Next .

And as I say, most of them really die very horribly, 80 is very bad for you. now that means, that is really bizarre that one should ask the question why should we defy aging.

Ultraviolet rays can cause skin cancer.

This would be sperm.

And then they start with the twin questions

We have more trials planned for lung cancer, pancreatic cancer, ovarian cancer and breast cancer.

In a female, they would be involved in the ovaries.

She goes home.

Difference human Neanderthal is sperm and testis, smell and skin.

These are animals whose lineage dates back about 100 million years.

It was pretty depressing.

So that means as their mate is sitting on the nest incubating the eggs, the other one is out there foraging, and the longer they have to stay gone, the worse condition the mate is in when the mate comes back.

And when it does it's not going to be that big a deal.

Identical twins have the same DNA.

Oeufs. Un oeuf, des oeufs.

As a concrete example maybe there are three types of breast cancers and so you may try to predict the discrete value of zero, one, two, or three with zero being benign.

I have chronic dermatitis.

Pigeon's Progress struck me as a catchy title.

I delivered identical twins.

I'm troubled with atopic dermatitis.

Now it's bad enough that breast density makes it hard to find a cancer, but it turns out that it's also a powerful predictor of your risk for breast cancer.

Then they're pupae. Then they come out as adult ants.

And the star on his skin?