And the bottom curve is the weight of a normal mouse.

So I went back to the biology of angiogenesis, and started thinking

Stop the treatment, it gains the weight back.

(Applause)

And in these situations, angiogenesis is out of balance.

His veterinarian only gave him three months to live.

In other words, we can't create supermodel mice.

There are antiangiogenic treatments that are FDA approved, and if you're a cancer patient, or working for one or advocating for one, you should ask about them.

So the body has the ability to regulate the amount of blood vessels that are present at any given time.

And this turns out to be one of our most important defense mechanisms against cancer.

This inhibits abnormal angiogenesis, by 60 percent.

And when angiogenesis is out of balance, a myriad of diseases result.

The active ingredient is resveratrol, it's also found in red wine.

Now, I've shown you a bunch of lab data, and so the real question is

And we're now studying the role of a healthy diet with Dean Ornish at UCSF and Tufts University the role of this healthy diet on markers of angiogenesis that we can find in the bloodstream.

legs without circulation, death from stroke, nerve damage.

Because it turns out that adipose tissue fat is highly angiogenesis dependent.

Fresh blood.

But starting in 2004, when antiangiogenic therapies first became available, you can see that there has been a 70 to 100 percent improvement in survival for people with kidney cancer, multiple myeloma, colorectal cancer, and gastrointestinal stromal tumors.

Blood flows through blood vessels.

It's gonna be going initially through a giant vessel.

Imagine if we could create the world's first rating system, in which we could score foods according to their antiangiogenic, cancer preventative properties.

And the capsules in her blood stream.

In fact, if you actually block angiogenesis and prevent blood vessels from ever reaching cancer cells, tumors simply can't grow up.

What could we be adding to our diet that's naturally antiangiogenic, and that could boost the body's defense system, and beat back those blood vessels that are feeding cancers?

But what we now know, is that for a number of diseases, there are defects in the system, where the body can't prune back extra blood vessels, or can't grow enough new ones in the right place at the right time.

And you can see that the halo of blood flow disappears after treatment.

Now, we know that tomatoes are a good source of lycopene, and lycopene is antiangiogenic.

Blood runs in the veins.

You know, where did these things come from?

So the shorter the bar, the less angiogenesis that's good.

Without angiogenesis, the tumor remains the size of a pinpoint and it's not harmful.

Cancer cells mutate, and they gain the ability to release lots of those angiogenic factors, natural fertilizer, that tip the balance in favor of blood vessels invading the cancer.

In effect, when we give cancer patients antiangiogenic therapy here, an experimental drug for a glioma, which is a type of brain tumor you can see that there are dramatic changes that occur when the tumor is being starved.

We can do this because tumor blood vessels are unlike normal, healthy vessels we see in other places of the body they're abnormal, they're very poorly constructed, and because of that, they're highly vulnerable to treatments that target them.

Therefore, when a tumor comes into skeletal muscle tissue, it can't get a blood supply, and can't grow.

Statins, nonsteroidal anti inflammatory drugs, and a few others they inhibit angiogenesis, too.

Shut your mouth!

So we created a cocktail of antiangiogenic drugs that could be mixed into his dog food, as well as an antiangiogenic cream, that could be applied on the surface of the tumor.

We've got 19 billion of them in our bodies.

like red blood cells.

(Laughter)

Subdural hematoma.

And this outer layer, this is the vasculature, which is incredible, around a human brain.

Thrombosis is the process of a thrombus forming.