Can I borrow a heart valve from you?

This is actually a heart valve, which we engineered.

And the way you engineer this heart valve is the same strategy.

So this valve is called the Tricuspid valve.

This is actually a heart valve that we've engineered, and you can see here, we have the structure of the heart valve and we've seeded that with cells, and then we exercise it.

And it passed through the valve here. So this valve is called the Mitral valve.

Civil Horizontal Valve

This is the second chamber of the heart. And it gets there by passing through the valve.

One will be the tricuspid valve and the other the mitral valve.

But before it goes it has to passed another valve. So this is a valve right here. Call it Pulmonary valve.

And this valve and all valves in the heart are basically there to keep blood moving in the right direction.

And the fact that pig heart valves have lots of these on them is the reason that you can't transplant a pig heart valve into a person easily.

The main valve is turned off.

Here you've got the aortic valve.

This is called a cycle valve tube.

Up here you have the pulmonary valve.

And then the final valve, I need to find a nice spot to write it maybe to right here, this final valve that passes through is called the Aortic valve.

You can see how the pulmonary and aortic valve are closed when the mitral and tricuspid valve are open.

So, the most beautiful thing I found at least what I think is the most beautiful in the book, is this heart valve.

Great and then I didn't hear from them for weeks, so I called, and I asked, What's going on with the heart valve?

And this is how you make a valve.

The low tech bit is that it's literally a pig's heart valve mounted in the high tech bit, which is a memory metal casing.

It's gonna go back perhaps through the mitral valve, it can go there, or it might go through the tricuspid valve.

So you see the leaflets opening and closing of this heart valve that's currently being used experimentally to try to get it to further studies.

I welded the breech, but the valve is still gaping.

Does the color of the valve matter? What matters here?

And they said, Well the director of the company decided not to let you borrow this heart valve, because want his product to be associated with pigs.

Anesthetize you, open your chest, put you on an artificial heart and lung machine, drop your body temperature to about 18 centigrade, stop your heart, cut the aorta out, replace it with a plastic valve and a plastic aorta.

Let's watch. (Sound of air escaping from valve) (Music) (Whirring sound)

And once it's in the right spot, they remove the outer shell, and the heart valve, well, it gets this shape and at that moment it starts beating, instantly.

Open the air inlet valve to supply compressed air to the machine

You can see two of the leaflets of the aortic valve working there.

Broken Heart

Assorted Heart

Heart Reverse

Heart disease.

One heart

Heart attack?

Heart attack.

Heart surgery?

Hot Heart

Hot heart

His heart.

My heart...

Heart cookies?