This is what happened to the children of the Dutch Hunger Winter.

On the far left, you see the purple line.

Maybe we should be asking ourselves, is it possible that insulin resistance causes weight gain and the diseases associated with obesity, at least in most people?

But what if we have it backwards?

They left my chest open for two weeks.

An obese man.

So what if we're fighting the wrong war, fighting obesity rather than insulin resistance?

He is overweight.

A fat boy, too !

And underlying these questions,

Cause and effect.

Let's look at some suggestive facts.

What'd I just watch? (men singing dramatic tune in Japanese) (kid screams) Aah!

I think he's 1 100 pounds of baby fat.

In addition, because obesity is not a unicentric epidemic, there's not a Patient Zero of the obesity epidemic if we find that guy, there was a spread of obesity out from him it's a multicentric epidemic.

Vicki. Victoria was an overweight Queen.

I suffer from obesity.

And the patients started drifting in.

And the bottom curve is the weight of a normal mouse.

But obviously the bigger problem that we all know about is obesity, and it's dramatic.

And I'll talk more about this, but the real epidemic isn't just heart disease or obesity or smoking it's loneliness and depression.

Americans have been told to eat less fat, the percent of calories from fat is down,

So my first topic with respect to this, was not death, but obesity.

So those seem like two bifurcated problems, but I kind of started to think about, you know, what is obesity and hunger?

I was fat as a boy.

Interestingly, one of those birth defects has seen a 200 percent increase in the U.S.

And in one generation, for example,

He's a fat boy.

And the next bar over, the red line, says if your friend's friends are obese, your risk of obesity is 25 percent higher.

The numbers are pretty crazy.

We can see that

Can we shrink fat by cutting off its blood supply?

I'm on my third generation of kids that they're getting bigger.

What with having no exercise and being overweight, he had a heart attack.

I did this and lost 40 pounds, weirdly while exercising less.

And just to show you this, this is from the CDC.

Are you packing it on?

Found them in the fat boy's stomach... mixed in with the food.

Now, most researchers believe obesity is the cause of insulin resistance.

And then the next line over says if your friend's friend's friend, someone you probably don't even know, is obese, your risk of obesity is 10 percent higher.

If it's very well connected, and this is well connected in a very local sense just in terms of the degree of the node or the number of neighbors that it has.

She is a selfish woman.

Logically, then, if you want to treat insulin resistance, you get people to lose weight, right?

He was well built, if not fat as such.

PCBs, DDT cross the placenta and effectively determine the likelihood of developing breast cancer and obesity and diabetes already when the baby's in the womb.