Then my father allowed me to proceed with my hope.

It's made a mistake.

18.Rare diseases

So the way we develop drugs now is by testing promising compounds on

Some of you may remember that.

It's similar to the pellagra epidemic in Mississippi in the '30s.

I'll show you an example of that real quickly.

OK. Now let's move from sleep to diseases.

These little chippies, these things are the size of a credit card.

So we know how to do this in many of the ways that are up there.

And this is something that sobers us in our field everyday in that, obviously, we've made remarkable impacts on cardiovascular disease, but look at cancer.

Because we understand very little about most human diseases.

How does that play out in terms of application to a disease?

No heart disease, nocturnal asthma or sleep apnea.

This was at a time that treatment actually existed in rich countries.

Do you think you might like to heal from your childhood?

I feel like i'm going clinically insane.

Let's move now to a more painful subject.

90 of people who die by suicide have a diagnosable and treatable mental illness at the time of their death.

Anders Breivik is merely evil.

300 to 500 million cases are reported.

I want to tell you about another disorder.

Now when we talk about suicide, there is also a medical contribution here.

She graduated NYU, she has a heart condition.

And I was rather taken aback.

These are years that we could get.

This is a place where the oldest living female population is found.

So dystonia is a disorder affecting children.

What I rather wish to say is that the humanity we all share is more important than the mental illness we may not.

So in this case, we are suppressing the activity of abnormal neurons.

But now let's apply that to systems diseases like cancer.

Three years later, he's ripping through boot camp. Attending physician calls the improvement in his bloodcell count miraculous.

I have Friedreich's ataxia, a neuromuscular disease.

Why does this matter?

About 80 of the body's immune cells reside in the gut, and immune abnormalities contribute to several neurological disorders.

We think there's a future to this.

By switching out that antibody, you can look at a different protein, thus, a different disease potentially any disease in the entire world.

Alright now. Attention, attention.

My grandfather was in prison during prohibition.

The death of Little Nell and Cordelia and all that sort of stuff just doesn't happen anymore.

And I believe that if we do this, and I believe that we can, that we will arrive at a fundamentally new paradigm for understanding and treating human disease, so that, in the future, if you go to seek the help of a health care professional, that it will in fact matter, if you're a male or a female the treatment that you receive, and not just, if you're going to see your gynecologist or your urologist.

And they were competitive about this

Your patient pulled through, I see.

Let's flip the table yet again

Elyn, you don't really understand